Ontology highlight
ABSTRACT:
SUBMITTER: Moiola CP
PROVIDER: S-EPMC6944435 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Moiola Cristian P CP De Luca Paola P Zalazar Florencia F Cotignola Javier J Rodríguez-Seguí Santiago A SA Gardner Kevin K Meiss Roberto R Vallecorsa Pablo P Pignataro Omar O Mazza Osvaldo O Vazquez Elba S ES De Siervi Adriana A
Clinical cancer research : an official journal of the American Association for Cancer Research 20140519 15
<h4>Purpose</h4>Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal-binding protein 1 (CtBP1) is a transcription repressor of tumor suppressor genes and is activated by NADH binding. High calorie intake decreases intracellular NAD(+)/NADH ratio. The aim of this work was to assess the effect of high-fat diet (HFD) and CtBP1 expression modulation over prostate xenograft growth.<h4>Expe ...[more]