Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data.

ABSTRACT: Schwann cells were identified in the tumor surrounding area prior to initiate the invasion process underlying connective tissue. These cells promote cancer invasion through direct contact, while paracrine signaling and matrix remodeling are not sufficient to proceed. Considering the intertwined structure of signaling, regulatory, and metabolic processes within a cell, we employed a genome-scale biomolecular network. Accordingly, a meta-analysis of Schwann cells associated transcriptomic datasets was performed, and the core information on differentially expressed genes (DEGs) was obtained by statistical analyses. Gene set over-representation analyses was performed on core DEGs to identify significantly functional and pathway enrichment analysis between Schwann cells and, lung adenocarcinoma

SUBMITTER: Silva VM 

PROVIDER: S-EPMC6944448 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature