Ontology highlight
ABSTRACT:
SUBMITTER: Uezu A
PROVIDER: S-EPMC6944460 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Uezu Akiyoshi A Hisey Erin E Kobayashi Yoshihiko Y Gao Yudong Y Bradshaw Tyler Wa TW Devlin Patrick P Rodriguiz Ramona R Tata Purushothama Rao PR Soderling Scott S
eLife 20191212
Human mutations in the dystroglycan complex (DGC) result in not only muscular dystrophy but also cognitive impairments. However, the molecular architecture critical for the synaptic organization of the DGC in neurons remains elusive. Here, we report Inhibitory Synaptic protein 1 (InSyn1) is a critical component of the DGC whose loss alters the composition of the GABAergic synapses, excitatory/inhibitory balance in vitro and in vivo, and cognitive behavior. Association of InSyn1 with DGC subunits ...[more]