Ontology highlight
ABSTRACT:
SUBMITTER: Estrada SM
PROVIDER: S-EPMC6944691 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Estrada Sarah M SM Thagard Andrew S AS Dehart Mary J MJ Damicis Jennifer R JR Dornisch Elisabeth M EM Ippolito Danielle L DL Burd Irina I Napolitano Peter G PG Ieronimakis Nicholas N
Cell death & disease 20200106 1
Prematurity is associated with perinatal neuroinflammation and injury. Screening for genetic modulators in an LPS murine model of preterm birth revealed the upregulation of Nr4a1, an orphan nuclear transcription factor that is normally absent or limited in embryonic brains. Concurrently, Nr4a1 was downregulated with magnesium sulfate (MgSO<sub>4</sub>) and betamethasone (BMTZ) treatments administered to LPS exposed dams. To understand the role of Nr4a1 in perinatal brain injury, we compared the ...[more]