Ontology highlight
ABSTRACT:
SUBMITTER: Flamier A
PROVIDER: S-EPMC6944693 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Flamier Anthony A Abdouh Mohamed M Hamam Rimi R Barabino Andrea A Patel Niraj N Gao Andy A Hanna Roy R Bernier Gilbert G
NPJ precision oncology 20200106
Glioblastoma multiforme (GBM) is an incurable primary brain tumor containing a sub-population of cancer stem cells (CSCs). Polycomb Repressive Complex (PRC) proteins BMI1 and EZH2 are enriched in CSCs, promoting clonogenic growth and resistance to genotoxic therapies. We report here that when used at appropriate concentrations, pharmaceutical inhibitors of BMI1 could efficiently prevent GBM colony growth and CSC self-renewal in vitro and significantly extend lifespan in terminally ill tumor-bear ...[more]