Ontology highlight
ABSTRACT:
SUBMITTER: Carney G
PROVIDER: S-EPMC6944712 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Carney Greg G Bassett Ken K Wright James M JM Maclure Malcolm M McGuire Nicolette N Dormuth Colin R CR
Alzheimer's & dementia (New York, N. Y.) 20191125
<h4>Introduction</h4>Cholinesterase inhibitors (ChEIs) are widely used to treat mild to moderate Alzheimer's disease and related dementia. Clinical trials have focused on placebo comparisons, inadequately addressing within-class comparative safety.<h4>Methods</h4>New users of ChEIs in British Columbia were categorized into five study cohorts: low-dose donepezil, high-dose donepezil, galantamine, rivastigmine patch, and oral rivastigmine. Comparative safety of ChEIs assessed hazard ratios using p ...[more]