Ontology highlight
ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC6945032 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dai Zhijun Z Long Nanye N Huang Wen W
G3 (Bethesda, Md.) 20200107 1
Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it's now possible to account for the majority of genetic variation through model fitting, prediction of phenotypes remains a challenge, especially across populations that have diverged in the past. In this study, we designed simulation experiments to specifically investigate the role of genetic interactions in failure of polygenic prediction. We foun ...[more]