Ontology highlight
ABSTRACT:
SUBMITTER: Kim SM
PROVIDER: S-EPMC6945033 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kim Seong M SM Tripathi Vishnu P VP Shen Kuo-Fang KF Forsburg Susan L SL
G3 (Bethesda, Md.) 20200107 1
From yeast to humans, the cell cycle is tightly controlled by regulatory networks that regulate cell proliferation and can be monitored by dynamic visual markers in living cells. We have observed S phase progression by monitoring nuclear accumulation of the FHA-containing DNA binding protein Tos4, which is expressed in the G1/S phase transition. We use Tos4 localization to distinguish three classes of DNA replication mutants: those that arrest with an apparent 1C DNA content and accumulate Tos4 ...[more]