C-reactive protein mediates the association between leisure-time physical activity and lung function in middle-aged and older adults.

ABSTRACT: BACKGROUND:Although previous studies have reported the benefits of physical activity (PA) to lung function in middle-aged and older adults, the biological mechanisms are still unclear. This study aimed to assess the extent to which C-reactive protein (CRP) mediates the association between leisure-time PA and lung function. METHODS:A population-based sample was recruited from English Longitudinal Study of Ageing (ELSA), Wave 6 (2012-2013). PA was self-reported by questionnaires. CRP was analyzed from peripheral blood. Lung function parameters including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured by using a spirometer. Baron and Kenny's causal steps method and multiple linear regression models based on the Karlson/Holm/Bree (KHB) method were used to a

SUBMITTER: Chen M 

PROVIDER: S-EPMC6945486 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature