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Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR).


ABSTRACT: BACKGROUND:Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors. We aimed to clarify the efficacy of dapagliflozin versus sitagliptin for modulating cardiometabolic risk factors including high glycated hemoglobin (HbA1c) levels, hypoglycemia, and body weight. METHODS:This prospective, randomized, open-label, blinded-endpoint, parallel-group trial enrolled 340 Japanese patients with early-stage type 2 diabetes receiving metformin alone or no glucose-lowering agents, who were randomized to receive dapagliflozin or sitagliptin for 24 weeks. The primary endpoint was the proportion of patients who achieved the composite endpoint of HbA1c level maintenance

SUBMITTER: Fuchigami A 

PROVIDER: S-EPMC6945792 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR).

Fuchigami Ayako A   Shigiyama Fumika F   Kitazawa Toru T   Okada Yosuke Y   Ichijo Takamasa T   Higa Mariko M   Hiyoshi Toru T   Inoue Ikuo I   Iso Kaoru K   Yoshii Hidenori H   Hirose Takahisa T   Kumashiro Naoki N  

Cardiovascular diabetology 20200107 1


<h4>Background</h4>Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors. We aimed to clarify the efficacy of dapagliflozin versus sitagliptin for modulating cardiometabolic risk factors including high glycated hemoglobin (HbA1c) levels, hypoglycemia, and body weight.<h4>Methods</h4>This prospective, randomized, open-label, blinded-endpoint, parallel-group trial enrolled 340 Japanese pa  ...[more]

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