Ontology highlight
ABSTRACT:
SUBMITTER: Soma S
PROVIDER: S-EPMC6946597 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Soma Shivatheja S Morgada Marcos N MN Naik Mandar T MT Boulet Aren A Roesler Anna A AA Dziuba Nathaniel N Ghosh Alok A Yu Qinhong Q Lindahl Paul A PA Ames James B JB Leary Scot C SC Vila Alejandro J AJ Gohil Vishal M VM
Cell reports 20191201 12
In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX2, is a complex process that requires metallochaperones and redox proteins including SCO1, SCO2, and COA6, a recently discovered protein whose molecular function is unknown. To uncover the molecular mechanism by which COA6 and SCO proteins mediate copper deli ...[more]