Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC6946678 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cao Huiling H Yan Qinnan Q Wang Dong D Lai Yumei Y Zhou Bo B Zhang Qi Q Jin Wenfei W Lin Simin S Lei Yiming Y Ma Liting L Guo Yuxi Y Wang Yishu Y Wang Yilin Y Bai Xiaochun X Liu Chuanju C Feng Jian Q JQ Wu Chuanyue C Chen Di D Cao Xu X Xiao Guozhi G
Bone research 20200102
Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse <i>Col1a1-Cre</i> transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse <i>Dmp1-Cre</i> transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but incre ...[more]