CDKN2A testing and genetic counseling promote reductions in objectively measured sun exposure one year later.

ABSTRACT: PURPOSE:This study investigated whether genetic counseling and test reporting for the highly penetrant CDKN2A melanoma predisposition gene promoted decreases in sun exposure. METHODS:A prospective, nonequivalent control group design compared unaffected participants (N?=?128, Mage?=?35.24, 52% men) from (1) families known to carry a CDKN2A pathogenic variant, who received counseling about management recommendations and a positive or negative genetic test result and (2) no-test control families known not to carry a CDKN2A pathogenic variant, who received equivalent counseling based on their comparable family history. Changes in daily ultraviolet radiation (UVR) exposure (J/m2), skin pigmentation (melanin index), and sunburns between baseline and one year following counseling were compared among carriers (n?=?32), noncarriers (n?=?46), and no-test control participants (n?=?50). RESULTS:Both carriers and no-test control participants exhibited a decrease one year later in daily UVR dose (B?=?-0.52, -0.33, p?

SUBMITTER: Stump TK 

PROVIDER: S-EPMC6946876 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature