Ontology highlight
ABSTRACT:
SUBMITTER: Sacchetto C
PROVIDER: S-EPMC6947282 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sacchetto Claudia C Sequeira Vasco V Bertero Edoardo E Dudek Jan J Maack Christoph C Calore Martina M
Journal of clinical medicine 20191212 12
The normal function of the heart relies on a series of complex metabolic processes orchestrating the proper generation and use of energy. In this context, mitochondria serve a crucial role as a platform for energy transduction by supplying ATP to the varying demand of cardiomyocytes, involving an intricate network of pathways regulating the metabolic flux of substrates. The failure of these processes results in structural and functional deficiencies of the cardiac muscle, including inherited car ...[more]