Ontology highlight
ABSTRACT:
SUBMITTER: Iacobaeus E
PROVIDER: S-EPMC6947442 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Iacobaeus Ellen E Kadri Nadir N Lefsihane Katia K Boberg Erik E Gavin Caroline C Törnqvist Andrén Anton A Lilja Anders A Brundin Lou L Blanc Katarina Le KL
Journal of clinical medicine 20191202 12
Bone marrow derived mesenchymal stromal cells (BM-MSCs) have emerged as a possible new therapy for Multiple Sclerosis (MS), however studies regarding efficacy and in vivo immune response have been limited and inconclusive. We conducted a phase I clinical study assessing safety and clinical and peripheral immune responses after MSC therapy in MS. Seven patients with progressive MS were intravenously infused with a single dose of autologous MSC (1-2 × 10<sup>6</sup> MSCs/kg body weight). The infus ...[more]