Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC6947929 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Xie Jingping J Wang Chunxia C Gore John C JC
Combinatorial chemistry & high throughput screening 20160101 3
The development of new anti-cancer therapeutic agents is necessary to improve antitumor efficacy and reduce toxicities. Here we report using a systematic anticancer drug screening approach we developed previously, to concurrently screen colon and glioma cancer cell lines for 2000 compounds with known bioactivity and 1920 compounds with unknown activity. The hits specific to each tumor cell line were then selected, and further tested with the same cells transfected with EGFP (Enhanced Green Fluor ...[more]