Ontology highlight
ABSTRACT:
SUBMITTER: Roger SD
PROVIDER: S-EPMC6947980 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Roger Simon D SD Spinowitz Bruce S BS Lerma Edgar V EV Singh Bhupinder B Packham David K DK Al-Shurbaji Ayman A Kosiborod Mikhail M
American journal of nephrology 20191028 6
<h4>Background</h4>Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is a selective potassium (K+) binder for treatment of hyperkalemia. An open-label extension (OLE) of the -HARMONIZE study evaluated efficacy and safety of SZC for ≤11 months.<h4>Methods</h4>Patients from HARMONIZE with point-of-care device i-STAT K+ 3.5-6.2 mmol/L received once-daily SZC 5-10 g for ≤337 days. End points included achievement of mean serum K+ ≤5.1 mmol/L (primary) or ≤5.5 mmol/L (secondary).<h4>Results</h4>Of 1 ...[more]