Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.
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ABSTRACT:
SUBMITTER: Hataye JM
PROVIDER: S-EPMC6948011 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.
Hataye Jason M JM Casazza Joseph P JP Best Katharine K Liang C Jason CJ Immonen Taina T TT Ambrozak David R DR Darko Samuel S Henry Amy R AR Laboune Farida F Maldarelli Frank F Douek Daniel C DC Hengartner Nicolas W NW Yamamoto Takuya T Keele Brandon F BF Perelson Alan S AS Koup Richard A RA
Cell host & microbe 20191121 6
A population at low census might go extinct or instead transition into exponential growth to become firmly established. Whether this pivotal event occurs for a within-host pathogen can be the difference between health and illness. Here, we define the principles governing whether HIV-1 spread among cells fails or becomes established by coupling stochastic modeling with laboratory experiments. Following ex vivo activation of latently infected CD4 T cells without de novo infection, stochastic cell ...[more]
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