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Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.


ABSTRACT: Background:Carnosinase-1 (CN-1) can be detected in 24?h urine of healthy individuals and patients with type 2 diabetes (T2DM). We aimed to assess whether urinary CN-1 is also reliably measured in spot urine and investigated its association with renal function and the albumin/creatinine ratio (ACR). We also assessed associations between the CNDP1 (CTG) n genotype and CN-1 concentrations in serum and urine. Methods:Patients with T2DM (n = 85) and nondiabetic patients with chronic kidney disease (CKD) (n = 26) stratified by albuminuria (ACR ? 300?mg/g or ACR > 300?mg/g) recruited from the nephrology clinic and healthy subjects (n = 24) were studied. Results:Urinary CN-1 was more frequently detected and displayed higher concentrations in patients with ACR > 300?mg/g as compared to those with ACR ? 300?mg/g irrespective of the baseline disease (T2DM: 554?ng/ml [IQR 212-934?ng/ml] vs. 31?ng/ml [IQR 31-63?ng/ml] (p < 0.0001) and nondiabetic CKD: 197?ng/ml [IQR 112-739] vs. 31?ng/ml [IQR 31-226?ng/ml] (p = 0.015)). A positive correlation between urinary CN-1 and ACR was found (r = 0.68, p < 0.0001). Multivariate linear regression analysis revealed that ACR and serum CN-1 concentrations but not eGFR or the CNDP1 genotype are independent predictors of urinary CN-1, explaining 47% of variation of urinary CN-1 concentrations (R 2 = 0.47, p < 0.0001). Conclusion:These results confirm and extend previous findings on urinary CN-1 concentrations, suggesting that assessment of CN-1 in spot urine is as reliable as in 24?h urine and may indicate that urinary CN-1 in macroalbuminuric patients is primarily serum-derived and not locally produced.

SUBMITTER: Rodriguez-Nino A 

PROVIDER: S-EPMC6948305 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Serum Carnosinase-1 and Albuminuria Rather than the <i>CNDP1</i> Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.

Rodriguez-Niño Angelica A   Hauske Sibylle J SJ   Herold Anna A   Qiu Jiedong J   van den Born Jacob J   Bakker Stephan J L SJL   Krämer Bernhard K BK   Yard Benito A BA  

Journal of diabetes research 20191224


<h4>Background</h4>Carnosinase-1 (CN-1) can be detected in 24 h urine of healthy individuals and patients with type 2 diabetes (T2DM). We aimed to assess whether urinary CN-1 is also reliably measured in spot urine and investigated its association with renal function and the albumin/creatinine ratio (ACR). We also assessed associations between the <i>CNDP1</i> (CTG) <i><sub>n</sub></i> genotype and CN-1 concentrations in serum and urine.<h4>Methods</h4>Patients with T2DM (<i>n</i> = 85) and nond  ...[more]

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