Ontology highlight
ABSTRACT:
SUBMITTER: Wu TY
PROVIDER: S-EPMC6948307 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wu Tsai-Yi TY Liang Ya-Han YH Wu Jiahn-Chun JC Wang Hwai-Shi HS
Stem cells international 20191227
The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1<i>β</i> induced LFA-1 expression on MSCs and ICAM-1 expression on HUVECs. We then pretreated MSCs with protein synthesis inhibitor cycloheximide. The results showed that IL-1<i>β</i> induced LFA-1 ...[more]