Ontology highlight
ABSTRACT:
SUBMITTER: Roberts RD
PROVIDER: S-EPMC6948723 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Roberts Ryan D RD Lizardo Michael M MM Reed Damon R DR Hingorani Pooja P Glover Jason J Allen-Rhoades Wendy W Fan Timothy T Khanna Chand C Sweet-Cordero E Alejandro EA Cash Thomas T Bishop Michael W MW Hegde Meenakshi M Sertil Aparna R AR Koelsche Christian C Mirabello Lisa L Malkin David D Sorensen Poul H PH Meltzer Paul S PS Janeway Katherine A KA Gorlick Richard R Crompton Brian D BD
Cancer 20190729 20
Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that patients have received over the last 4 decades. Extensive efforts to identify more effective or less toxic regimens have proved disappointing. As we enter a postgenomic era in which we now recognize OS not as a cancer of mutations but as one defined by p53 loss, chromosomal complexity, copy number alteration, and profound heterogeneity, emerging threads of discovery leave many hopeful that an improving understa ...[more]