Ontology highlight
ABSTRACT:
SUBMITTER: Ranjit S
PROVIDER: S-EPMC6948756 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ranjit Sanjay S Wong Jian Yao JY Wong Jian Yao JY Tan Jia W JW Sin Tay Chee C Lee Jessica M JM Yin Han Wong Kelly K Pojoga Luminita H LH Brooks Danielle L DL Garza Amanda E AE Maris Stephen A SA Katayama Isis Akemi IA Williams Jonathan S JS Rivera Alicia A Adler Gail K GK Williams Gordon H GH Romero Jose R JR
JCI insight 20191101 21
Salt sensitivity of blood pressure (SSBP) and hypertension are common, but the underlying mechanisms remain unclear. Endoplasmic reticulum aminopeptidase 1 (ERAP1) degrades angiotensin II (ANGII). We hypothesized that decreasing ERAP1 increases BP via ANGII-mediated effects on aldosterone (ALDO) production and/or renovascular function. Compared with WT littermate mice, ERAP1-deficient (ERAP1+/-) mice had increased tissue ANGII, systolic and diastolic BP, and SSBP, indicating that ERAP1 deficienc ...[more]