Ontology highlight
ABSTRACT:
SUBMITTER: Muller D
PROVIDER: S-EPMC6948775 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Müller David D Shin Sauyeun S Goullet de Rugy Théo T Samain Rémi R Baer Romain R Strehaiano Manon M Masvidal-Sanz Laia L Guillermet-Guibert Julie J Jean Christine C Tsukumo Yoshinori Y Sonenberg Nahum N Marion Frédéric F Guilbaud Nicolas N Hoffmann Jean-Sébastien JS Larsson Ola O Bousquet Corinne C Pyronnet Stéphane S Martineau Yvan Y
JCI insight 20191101 21
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1. Using genome-wide polysome profiling, we here explore mRNAs whose translational efficiencies depend on the mTOR/4E-BP1 axis in pancreatic cancer cells. We identified a functional enrichment for mRNAs encoding DNA replication and repair proteins, including RRM2 and CDC6. Consequently, 4E-BP1 depletion favors D ...[more]