Ontology highlight
ABSTRACT:
SUBMITTER: de Castro PA
PROVIDER: S-EPMC6948819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
de Castro Patrícia Alves PA Colabardini Ana Cristina AC Manfiolli Adriana Oliveira AO Chiaratto Jéssica J Silva Lilian Pereira LP Mattos Eliciane Cevolani EC Palmisano Giuseppe G Almeida Fausto F Persinoti Gabriela Felix GF Ries Laure Nicolas Annick LNA Mellado Laura L Rocha Marina Campos MC Bromley Michael M Silva Roberto Nascimento RN de Souza Gabriel Scalini GS Loures Flávio Vieira FV Malavazi Iran I Brown Neil Andrew NA Goldman Gustavo H GH
PLoS genetics 20191230 12
Aspergillus fumigatus causes invasive aspergillosis, the most common life-threatening fungal disease of immuno-compromised humans. The treatment of disseminated infections with antifungal drugs, including echinocandin cell wall biosynthesis inhibitors, is increasingly challenging due to the rise of drug-resistant pathogens. The fungal calcium responsive calcineurin-CrzA pathway influences cell morphology, cell wall composition, virulence, and echinocandin resistance. A screen of 395 A. fumigatus ...[more]