Keratinocyte-derived I?B? drives psoriasis and associated systemic inflammation.

ABSTRACT: The transcriptional activator I?B? is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that I?B? expression in keratinocytes triggers not only skin lesions but also systemic inflammation in mouse psoriasis models. Specific depletion of I?B? in keratinocytes was sufficient to suppress the induction of imiquimod- or IL-36-mediated psoriasis. Moreover, I?B? ablation in keratinocytes prevented the onset of psoriatic lesions and systemic inflammation in keratinocyte-specific IL-17A-transgenic mice. Mechanistically, this psoriasis protection was mediated by I?B? deficiency in keratinocytes abrogating the induction of specific proinflammatory target genes, including Cxcl5, Cxcl2, Csf2, and Csf3, in response to IL-17A or IL-36. These I?B?-dependent genes trigger the generation and recruitment of neutrophils and monocytes that are needed for skin inflammation. Consequently, our data uncover a surprisingly pivotal role of keratinocytes and keratinocyte-derived I?B? as key mediators of psoriasis and psoriasis-related systemic inflammation.

SUBMITTER: Lorscheid S 

PROVIDER: S-EPMC6948851 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature