Dataset Information

Body composition reference charts for UK infants and children aged 6 weeks to 5 years based on measurement of total body water by isotope dilution.

ABSTRACT:

Background

Until recently, pediatric body composition reference data were very limited, hindering interpretation of measurements. In the last decade, such data emerged for several techniques for children???5 years, but equivalent data for younger age groups remain lacking, due to their poor compliance with most techniques.

Objectives

To provide reference data for use in clinical practice and research from 6 weeks to 5 years, that are based on measurements of total body water (TBW) by isotope dilution.

Design

The data on anthropometry and TBW were available from studies of 463 infants and children aged 6 weeks to 7 years, conducted between 1988 and 2010. Both breast-fed and formula-fed infants were included. TBW was measured by ²H- or ¹⁸O-labeled water, and converted to fat-free mass (FFM) using published hydration coefficients. Reference charts and SD scores (SDS) were constructed for FFM, fat mass (FM), FFM index and FM index for each sex, using the lambda-mu-sigma method.

Results

Both sexes were significantly heavier and longer than UK 1990 reference data (p?ConclusionsThese reference data will enhance the ability of clinicians to assess and monitor body composition and FFM/FM accretion in clinical practice in younger age groups. Total body water can be measured in most patients, though abnormalities of hydration must be addressed. However, the centiles do not overlap exactly with those published for older age groups, limiting comparability between younger and older children.

SUBMITTER: Wells JCK

PROVIDER: S-EPMC6949189 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Body composition reference charts for UK infants and children aged 6 weeks to 5 years based on measurement of total body water by isotope dilution.

Wells Jonathan C K JCK Davies Peter S W PSW Fewtrell Mary S MS Cole Tim J TJ

European journal of clinical nutrition 20190226 1

<h4>Background</h4>Until recently, pediatric body composition reference data were very limited, hindering interpretation of measurements. In the last decade, such data emerged for several techniques for children ≥ 5 years, but equivalent data for younger age groups remain lacking, due to their poor compliance with most techniques.<h4>Objectives</h4>To provide reference data for use in clinical practice and research from 6 weeks to 5 years, that are based on measurements of total body water (TBW) ...[more]

PMID: 30809008

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Dataset Information

Body composition reference charts for UK infants and children aged 6 weeks to 5 years based on measurement of total body water by isotope dilution.

Background

Objectives

Design

Results

Publications

Body composition reference charts for UK infants and children aged 6 weeks to 5 years based on measurement of total body water by isotope dilution.

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