Non-invasive molecular tracking method that measures ocular drug distribution in non-human primates.
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ABSTRACT:
SUBMITTER: Normand G
PROVIDER: S-EPMC6949284 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Non-invasive molecular tracking method that measures ocular drug distribution in non-human primates.
Normand Guillaume G Maker Michael M Penraat Jan J Kovach Kellyann K Ghosh Joy G JG Grosskreutz Cynthia C Chandra Sudeep S
Communications biology 20200108 1
Intravitreal (IVT) injection has become the standard route for drug administration in retinal diseases. However, the ability to measure biodistribution of ocular therapeutics in large species remains limited, due to the invasive nature of some techniques or their lack of spatial information. The aim of this study was to develop in cynomolgus monkeys a non-invasive fluorescence imaging technology that enables tracking of IVT-dosed drugs and could be easily translated into humans. Here, we show a ...[more]
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