ULK1 phosphorylates Exo70 to suppress breast cancer metastasis.
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ABSTRACT:
SUBMITTER: Mao L
PROVIDER: S-EPMC6949295 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis.
Mao Liyuan L Zhan Yan-Yan YY Wu Bin B Yu Qiang Q Xu Liang L Hong Xiaoting X Zhong Linhai L Mi Panying P Xiao Li L Wang Xinquan X Cao Hanwei H Zhang Wenqing W Chen Binbin B Xiang Jingzhou J Mei Kunrong K Radhakrishnan Ravi R Guo Wei W Hu Tianhui T
Nature communications 20200108 1
Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of the exocyst complex. ULK1 phosphorylation inhibits Exo70 homo-oligomerization as well as its assembly to the exocyst complex, which are needed for cell protrusion formation and matrix metalloproteinas ...[more]
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