Dataset Information

Development and initial validation of the Asthma Severity Scoring System (ASSESS).

ABSTRACT:

Background

Tools for quantification of asthma severity are limited.

Objective

We sought to develop a continuous measure of asthma severity, the Asthma Severity Scoring System (ASSESS), for adolescents and adults, incorporating domains of asthma control, lung function, medications, and exacerbations.

Methods

Baseline and 36-month longitudinal data from participants in phase 3 of the Severe Asthma Research Program (NCT01606826) were used. Scale properties, responsiveness, and a minimally important difference were determined. External replication was performed in participants enrolled in the Severe Asthma Research Program phase 1/2. The utility of ASSESS for detecting treatment response was explored in participants undergoing corticosteroid responsiveness testing with intramuscular triamcinolone and participants receiving biologics.

Results

ASSESS scores ranged from 0 to 20 (8.78 ± 3.9; greater scores reflect worse severity) and differed among 5 phenotypic groups. Measurement properties were acceptable. ASSESS was responsive to changes in quality of life with a minimally important difference of 2, with good specificity for outcomes of asthma improvement and worsening but poor sensitivity. Replication analyses yielded similar results, with a 2-point decrease (improvement) associated with improvements in quality of life. Participants with a 2-point or greater decrease (improvement) in ASSESS scores also had greater improvement in lung function and asthma control after triamcinolone, but these differences were limited to phenotypic clusters 3, 4, and 5. Participants treated with biologics also had a 2-point or greater decrease (improvement) in ASSESS scores overall.

Conclusions

The ASSESS tool is an objective measure that might be useful in epidemiologic and clinical research studies for quantification of treatment response in individual patients and phenotypic groups. However, validation studies are warranted.

SUBMITTER: Fitzpatrick AM

PROVIDER: S-EPMC6949388 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Development and initial validation of the Asthma Severity Scoring System (ASSESS).

Fitzpatrick Anne M AM Szefler Stanley J SJ Mauger David T DT Phillips Brenda R BR Denlinger Loren C LC Moore Wendy C WC Sorkness Ronald L RL Wenzel Sally E SE Gergen Peter J PJ Bleecker Eugene R ER Castro Mario M Erzurum Serpil C SC Fahy John V JV Gaston Benjamin M BM Israel Elliot E Levy Bruce D BD Meyers Deborah A DA Teague W Gerald WG Bacharier Leonard B LB Ly Ngoc P NP Phipatanakul Wanda W Ross Kristie R KR Zein Joe J Jarjour Nizar N NN

The Journal of allergy and clinical immunology 20191008 1

<h4>Background</h4>Tools for quantification of asthma severity are limited.<h4>Objective</h4>We sought to develop a continuous measure of asthma severity, the Asthma Severity Scoring System (ASSESS), for adolescents and adults, incorporating domains of asthma control, lung function, medications, and exacerbations.<h4>Methods</h4>Baseline and 36-month longitudinal data from participants in phase 3 of the Severe Asthma Research Program (NCT01606826) were used. Scale properties, responsiveness, and ...[more]

PMID: 31604088

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Dataset Information

Development and initial validation of the Asthma Severity Scoring System (ASSESS).

Background

Objective

Methods

Results

Conclusions

Publications

Development and initial validation of the Asthma Severity Scoring System (ASSESS).

Similar Datasets

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