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Polymorph evolution during crystal growth studied by 3D electron diffraction.

ABSTRACT: 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order ? < ? < ?. The least stable ? polymorph forms within the first 3?min, but this begins to yield the ?-form after only 1?min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20?s on crystals of thickness ?100?nm. Even though the ?-form is thermodynamically the most stable polymorph, kinetics favour the ?-form, which dominates after prolonged standing. In the same sample, some ? and one crystallite of the ? polymorph were also observed.

SUBMITTER: Broadhurst ET

PROVIDER: S-EPMC6949601 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Polymorph evolution during crystal growth studied by 3D electron diffraction.

Broadhurst Edward T ET Xu Hongyi H Clabbers Max T B MTB Lightowler Molly M Nudelman Fabio F Zou Xiaodong X Parsons Simon S

IUCrJ 20200101 Pt 1

3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼10 ...[more]

PMID: 31949899

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