Ontology highlight
ABSTRACT:
SUBMITTER: Mehran S
PROVIDER: S-EPMC6949734 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mehran Shiva S Rasmi Yousef Y Karamdel Hamid Reza HR Hossinzadeh Ramin R Gholinejad Zafar Z
Evidence-based complementary and alternative medicine : eCAM 20191224
<h4>Introduction</h4>Wortmannin (WTN) is a steroid metabolite that inhibits phosphatidylinositol 3-kinase and other signaling pathways. Structurally, the WTN consists of a cyclopentanophenanthrene-like structure with several oxygen-rich moieties which have the potential to interact with deoxyribonucleic acid (DNA) molecules.<h4>Methods</h4>We aim to evaluate the WTN and calf thymus DNA (ct-DNA) interaction with molecular docking using the AutoDock 4.2 software. UV and fluorescence spectroscopy a ...[more]