Ontology highlight
ABSTRACT:
SUBMITTER: Tiwari A
PROVIDER: S-EPMC6951913 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Tiwari Abhinav A Bhattacharya Indranil I Chan Phylinda L S PLS Harnisch Lutz L
Clinical and translational science 20191024 1
Modeling and simulation provides quantitative information on target coverage for dose selection. Optimal model selection often relies on fit criteria and is not necessarily mechanistically driven. One such case is discussed where healthy volunteer data of an anti-myostatin monoclonal antibody domagrozumab were used to develop different target-mediated drug disposition models; a quasi-steady state (QSS) rapid binding approximation model, a Michaelis-Menten (MM)-binding kinetics (MM-BK) model, and ...[more]