Ontology highlight
ABSTRACT:
SUBMITTER: Bauer J
PROVIDER: S-EPMC6952350 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bauer Jessica J Emon Md Abul Bashar MAB Staudacher Jonas J JJ Thomas Alexandra L AL Zessner-Spitzenberg Jasmin J Mancinelli Georgina G Krett Nancy N Saif M Taher MT Jung Barbara B
Scientific reports 20200109 1
Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical biophysical role in cancer progression, but the precise pro-metastatic mechanisms are not clear. Activin A, a TGF-β family member, is a strong pro-metastatic cytokine in the context of CRC. Here, we assessed the link between biophysical forces and pro-metastatic signaling by testing the hypothesis that CAF-generate ...[more]