Ontology highlight
ABSTRACT:
SUBMITTER: Ay B
PROVIDER: S-EPMC6952406 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ay Birol B Parolia Kushagra K Liddell Robert S RS Qiu Yusheng Y Grasselli Giovanni G Cooper David M L DML Davies John E JE
Communications biology 20200109 1
Uncontrolled diabetes is associated with increased risk of bony fractures. However, the mechanisms have yet to be understood. Using high-resolution synchrotron micro-CT, we calculated the changes in the microstructure of femoral cortices of streptozotocin-induced hyperglycemic (STZ) Wistar Albino rats and tested the mechanical properties of the mineralized matrix by nanoindentation. Total lacunar volume of femoral cortices increased in STZ group due to a 9% increase in lacunar density. However, ...[more]