Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

µ-PIV Measurements of Flows Generated by Photolithography-Fabricated Achiral Microswimmers.

ABSTRACT: Robotic micro/nanoswimmers can potentially be used as tools for medical applications, such as drug delivery and noninvasive surgery. Recently, achiral microswimmers have gained significant attention because of their simple structures, which enables high-throughput fabrication and size scalability. Here, microparticle image velocimetry (µ-PIV) was used to study the hydrodynamics of achiral microswimmers near a boundary. The structures of these microswimmers resemble the letter L and were fabricated using photolithography and thin-film deposition. Through µ-PIV measurements, the velocity flow fields of the microswimmers rotating at different frequencies were observed. The results herein yield an understanding of the hydrodynamics of the L-shaped microswimmers, which will be useful in applications such as fluidic manipulation.

SUBMITTER: Tan L

PROVIDER: S-EPMC6953064 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

µ-PIV Measurements of Flows Generated by Photolithography-Fabricated Achiral Microswimmers.

Tan Liyuan L Ali Jamel J Cheang U Kei UK Shi Xiangcheng X Kim Dalhyung D Kim Min Jun MJ

Micromachines 20191210 12

Robotic micro/nanoswimmers can potentially be used as tools for medical applications, such as drug delivery and noninvasive surgery. Recently, achiral microswimmers have gained significant attention because of their simple structures, which enables high-throughput fabrication and size scalability. Here, microparticle image velocimetry (µ-PIV) was used to study the hydrodynamics of achiral microswimmers near a boundary. The structures of these microswimmers resemble the letter L and were fabricat ...[more]

PMID: 31835453

Similar Datasets

Stop-Flow Lithography for the Continuous Production of Degradable Hydrogel Achiral Crescent Microswimmers.

Project description:The small size of robotic microswimmers makes them suitable for performing biomedical tasks in tiny, enclosed spaces. Considering the effects of potentially long-term retention of microswimmers in biological tissues and the environment, the degradability of microswimmers has become one of the pressing issues in this field. While degradable hydrogel was successfully used to prepare microswimmers in previous reports, most hydrogel microswimmers could only be fabricated using two-photon polymerization (TPP) due to their 3D structures, resulting in costly robotic microswimmers solution. This limits the potential of hydrogel microswimmers to be used in applications where a large number of microswimmers are needed. Here, we proposed a new type of preparation method for degradable hydrogel achiral crescent microswimmers using a custom-built stop-flow lithography (SFL) setup. The degradability of the hydrogel crescent microswimmers was quantitatively analyzed, and the degradation rate in sodium hydroxide solution (NaOH) of different concentrations was investigated. Cytotoxicity assays showed the hydrogel crescent microswimmers had good biocompatibility. The hydrogel crescent microswimmers were magnetically actuated using a 3D Helmholtz coil system and were able to obtain a swimming efficiency on par with previously reported microswimmers. The results herein demonstrated the potential for the degradable hydrogel achiral microswimmers to become a candidate for microscale applications.

| S-EPMC9144168 | biostudies-literature

Photolithography Fabricated Spacer Arrays Offering Mechanical Strengthening and Oil Motion Control in Electrowetting Displays.

Project description:Introducing spacers into pixelated electrowetting displays (EWDs) normally gives mechanical strengthening, while bringing undesired disturbance of water/oil interfacial dynamics. Hence, spacer array is a key pixel structure needs careful consideration in the design and fabrication of electrowetting displays. Here, we propose a spacer array, which is designed standing on the junction of adjacent pixel walls, fabricated by photolithography. The spacer array provides mechanical strength enhancement and reliable oil motion controllability. By optimizing the spacer distribution density, the EWD device may achieve 28% increase in open ratio (white area fraction) and withstand 60 N/mm2 pressure. This design of spacer array reasonably solves the contradiction between mechanical strength enhancement and optoelectronic performance in EWDs, providing potential applications in oil-water two-phase microfluidic devices.

| S-EPMC7014117 | biostudies-literature

Turbulent dispersion via fan-generated flows.

Project description:Turbulent dispersion of passive scalar quantities has been extensively studied in wind tunnel settings, where the flow is carefully conditioned using flow straighteners and grids. Much less is known about turbulent dispersion in the "unconditioned" flows generated by fans that are ubiquitous in indoor environments, despite the importance of these flows to pathogen and contaminant transport. Here, we demonstrate that a point source of scalars released into an airflow generated by an axial fan yields a plume whose width is invariant with respect to the fan speed. The results point toward a useful simplification in modeling of disease and pollution spread via fan-generated flows.

| S-EPMC4039734 | biostudies-other

Motility and chemotaxis of bacteria-driven microswimmers fabricated using antigen 43-mediated biotin display.

Project description:Bacteria-driven biohybrid microswimmers (bacteriabots) combine synthetic cargo with motile living bacteria that enable propulsion and steering. Although fabrication and potential use of such bacteriabots have attracted much attention, existing methods of fabrication require an extensive sample preparation that can drastically decrease the viability and motility of bacteria. Moreover, chemotactic behavior of bacteriabots in a liquid medium with chemical gradients has remained largely unclear. To overcome these shortcomings, we designed Escherichia coli to autonomously display biotin on its cell surface via the engineered autotransporter antigen 43 and thus to bind streptavidin-coated cargo. We show that the cargo attachment to these bacteria is greatly enhanced by motility and occurs predominantly at the cell poles, which is greatly beneficial for the fabrication of motile bacteriabots. We further performed a systemic study to understand and optimize the ability of these bacteriabots to follow chemical gradients. We demonstrate that the chemotaxis of bacteriabots is primarily limited by the cargo-dependent reduction of swimming speed and show that the fabrication of bacteriabots using elongated E. coli cells can be used to overcome this limitation.

| S-EPMC6023875 | biostudies-literature

Hollow Microneedles on a Paper Fabricated by Standard Photolithography for the Screening Test of Prediabetes.

Project description:Microneedle (MN) is a novel technique of the biomedical engineering field because of its ability to evaluate bioinformation via minimal invasion. One of the urgent requirements for ground-breaking health care monitoring is persistent monitoring. Hollow microneedles are extremely attractive to extract skin interstitial fluid (ISF) for analysis, which makes them perfect for sensing biomarkers and facilitating diagnosis. Nevertheless, its intricate fabrication process has hampered its extensive application. The present research demonstrates an easy one-step preparation approach for hollow MNs on the foundation of the refraction index variations of polyethylene glycol diacrylate (PEGDA) in the process of photopolymerization. The fabricated hollow microneedle exhibited ideal mechanical characteristics to penetrate the skin. Hydrodynamic simulations showed that the liquid was risen in a hollow microneedle by capillary force. Furthermore, a paper-based glucose sensor was integrated with the hollow microneedle. We also observed that the MN array smoothly extracted ISF in vitro and in vivo by capillary action. The outcomes displayed the applicability of the MN patch to persistent blood glucose (GLU) monitoring, diagnosis-related tests for patients and pre-diabetic individuals.

| S-EPMC9185271 | biostudies-literature

Strong Transient Flows Generated by Thermoplasmonic Bubble Nucleation.

Project description:The challenge of inducing and controlling localized fluid flows for generic force actuation and for achieving efficient mass transport in microfluidics is key to the development of next-generation miniaturized systems for chemistry and life sciences. Here we demonstrate a methodology for the robust generation and precise quantification of extremely strong flow transients driven by vapor bubble nucleation on spatially isolated plasmonic nanoantennas excited by light. The system is capable of producing peak flow speeds of the order mm/s at modulation rates up to ∼100 Hz in water, thus allowing for a variety of high-throughput applications. Analysis of flow dynamics and fluid viscosity dependence indicates that the transient originates in the rapid bubble expansion that follows nucleation rather than being strictly thermocapillary in nature.

| S-EPMC7760215 | biostudies-literature

Two-ring chirality generated by the alignment of two achiral phenylacetylene macrocycles.

Project description:When two achiral rings are bound mechanically, a chiral source is generated in the assembly. The chiroptical properties could be modulated according to the relative occupation of each ring in the assembly. In fact, we have found that two isomeric assemblies (1 and 2) show unique properties in each assembly with two achiral rings of phenylacetylene macrocycle (PAM). When considering the difference in the chiroptical properties of these two isomeric assemblies (6PAM × 2), no comparison was available based on no activity of the achiral component element itself (6PAM). In this work, we synthesized a two-ring chiral analog (4) by the ring-fusion of two 6PAMs to an 11PAM, and examined the chiroptical properties of 4, since the single helix was imparted as a chiral source. By comparison of the chiroptical properties (molar circular dichroism and molar optical rotation) of 1 and 2 to those of 4, we demonstrated that the disparity was related to the alignment of the two achiral rings.

| S-EPMC10102884 | biostudies-literature

Synchronous PIV measurements of a self-powered blood turbine and pump couple for right ventricle support.

Project description:A blood turbine-pump system (iATVA), resembling a turbocharger was proposed as a mechanical right-heart assist device without external drive power. In this study, the iATVA system is investigated with particular emphasis on the blood turbine flow dynamics. A time-resolved 2D particle image velocimetry (PIV) set-up equipped with a beam splitter and two high speed cameras, allowed simultaneous recordings from both the turbine and pump impellers at 7 different phased-locked instances. The iATVA prototype is 3D printed using an optically clear resin following our earlier PIV protocols. Results showed that magnetically coupled impellers operated synchronously. As the turbine flow rate increased from 1.6 to 2.4 LPM, the rotational speed and relative inlet flow angle increase from 630 to 900 rpm, and 38 to 55% respectively. At the trailing edges, backflow region spanned 3/5 of the total passage outlet flow, and an extra leakage flow was observed at the leading edge. For this early turbine design, approximately, 75% of the turbine blade passage was not contributing to the impulse operation mode. The maximum non-wall shear rate was ~ 2288 s-1 near to the inlet exit, which is significantly lower than the commercial blood pumps, encouraging further research and blood experiments of this novel concept. Experimental results will improve the hydrodynamic design of the turbine impeller and volute regions and will be useful in computational fluid dynamics validation studies of similar passive devices.

| S-EPMC11358467 | biostudies-literature

CMOS compatible high-Q photonic crystal nanocavity fabricated with photolithography on silicon photonic platform.

Project description:Progress on the fabrication of ultrahigh-Q photonic-crystal nanocavities (PhC-NCs) has revealed the prospect for new applications including silicon Raman lasers that require a strong confinement of light. Among various PhC-NCs, the highest Q has been recorded with silicon. On the other hand, microcavity is one of the basic building blocks in silicon photonics. However, the fusion between PhC-NCs and silicon photonics has yet to be exploited, since PhC-NCs are usually fabricated with electron-beam lithography and require an air-bridge structure. Here we show that a 2D-PhC-NC fabricated with deep-UV photolithography on a silica-clad silicon-on-insulator (SOI) structure will exhibit a high-Q of 2.2 × 10(5) with a mode-volume of ~ 1.7(λ/n)(3). This is the highest Q demonstrated with photolithography. We also show that this device exhibits an efficient thermal diffusion and enables high-speed switching. The demonstration of the photolithographic fabrication of high-Q silica-clad PhC-NCs will open possibility for mass-manufacturing and boost the fusion between silicon photonics and CMOS devices.

| S-EPMC4471896 | biostudies-other

Time-Resolved Measurements of Turbulent Mixing in Shock-Driven Variable-Density Flows.

Project description:Recent developments of burst-mode lasers and imaging systems have opened new realms of simultaneous diagnostics for velocity and density fields at a rate of 1?kHz-1?MHz. These enable the exploration of previously unimaginable shock-driven turbulent flow fields that are of significant importance to problems in high-energy density physics. The current work presents novel measurements using simultaneous measurements of velocity and scalar fields at 60?kHz to investigate Richtmyer-Meshkov instability (RMI) in a spatio-temporal approach. The evolution of scalar fields and the vorticity dynamics responsible for the same are shown, including the interaction of shock with the interface. This temporal information is used to validate two vorticity-deposition models commonly used for initiation of large scale simulations, and have been previously validated only via simulations or integral measures of circulation. Additionally, these measurements also enable tracking the evolution and mode merging of individual flow structures that were previously not possible owing to inherently random variations in the interface at the smallest scales. A temporal evolution of symmetric vortex merging and the induced mixing prevalent in these problems is presented, with implications for the vortex paradigms in accelerated inhomogenous flows.

| S-EPMC6937284 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data