Ontology highlight
ABSTRACT:
SUBMITTER: Mishra SK
PROVIDER: S-EPMC6953176 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Mishra Sambit Kumar SK Sankar Kannan K Jernigan Robert L RL
Proteins 20170427 8
It is known that over half of the proteins encoded by most organisms function as oligomeric complexes. Oligomerization confers structural stability and dynamics changes in proteins. We investigate the effects of oligomerization on protein dynamics and its functional significance for a set of 145 multimeric proteins. Using coarse-grained elastic network models, we inspect the changes in residue fluctuations upon oligomerization and then compare with residue conservation scores to identify the fun ...[more]