Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats.

ABSTRACT: Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack of consensus to regard estrogen as a variable when working with animal models; thus, the influence of hormones' fluctuations on nociception has continually been neglected. In the present study, we designed a novel hormone substitution model to aid us to evaluate the effects of estrogen's long-term alterations on ovariectomy (OVX)-induced mechanical hyperalgesia and the expression of estrogen receptors(ERs). OVX rats were implanted with slow-release estrogen pellets at differently arranged time points and doses, such that a gradual elevation or decrease of serum estrogen levels following a relatively stable per

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6953313 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature