Ontology highlight
ABSTRACT:
SUBMITTER: Zost SJ
PROVIDER: S-EPMC6953393 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cell reports 20191201 13
Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby variable HA residues. Here, we identify several human H3N2 HA RBS-targeting monoclonal antibodies (mAbs) that are sensitive to substitutions in conventional antigenic sites and are therefore not broadly reactive. However, we also identify an H3N2 HA RBS-targeting mAb that is exceptionally broadly ...[more]