Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.
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ABSTRACT:
SUBMITTER: Gelernter J
PROVIDER: S-EPMC6953633 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.
Gelernter Joel J Sun Ning N Polimanti Renato R Pietrzak Robert R Levey Daniel F DF Bryois Julien J Lu Qiongshi Q Hu Yiming Y Li Boyang B Radhakrishnan Krishnan K Aslan Mihaela M Cheung Kei-Hoi KH Li Yuli Y Rajeevan Nallakkandi N Sayward Frederick F Harrington Kelly K Chen Quan Q Cho Kelly K Pyarajan Saiju S Sullivan Patrick F PF Quaden Rachel R Shi Yunling Y Hunter-Zinck Haley H Gaziano J Michael JM Concato John J Zhao Hongyu H Stein Murray B MB
Nature neuroscience 20190729 9
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight ...[more]
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