Ontology highlight
ABSTRACT:
SUBMITTER: Trucco EM
PROVIDER: S-EPMC6953736 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Trucco Elisa M EM Madan Brigitte B Villar Michelle M
Current addiction reports 20190903 4
<h4>Purpose</h4>This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.<h4>Findings</h4>Prior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neur ...[more]