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Umbilical cord separation time, predictors and healing complications in newborns with dry care.

ABSTRACT: OBJECTIVE:The objective of this study was to explore the umbilical cord separation time, predictors, and healing complications from birth until the newborn was one month old. DESIGN:A quantitative longitudinal observational analytical study by stratified random sample was adopted. SETTING:Public health system hospitals in southern Spain and at newborns' homes. PARTICIPANTS:Between April 2016 and December 2017, the study included 106 neonates born after 35-42 weeks of gestation whose umbilical cord was cured with water and soap and dried later as well as newborns without umbilical canalisation whose mothers enjoyed a low-risk pregnancy. METHODS:The data collection procedure comprised two blocks: from birth to the time of separation of the umbilical cord and from cord separation to the first month of life of the newborn. Umbilical cord separation time was measured in minutes; socio-demographic and clinical characteristics were measured by means of questionnaires, and the external diameter of the umbilical cord was measured using an electronic stainless-steel calliper and trailing roller. RESULTS:The mean umbilical separation time: 6.61 days (±2.33, IC 95%:6.16-7.05). Incidence of omphalitis was 3.7%; granuloma was 8.6%. Separation time predictors were wetting recurrence, birth weight, intrapartum antibiotics, birth season, and Apgar < 9 (R2 = 0.439 F: 15.361, p <0.01). CONCLUSION:The findings support the World Health Organization recommendations: dry umbilical cord cares is a safe practice that soon detaches the umbilical cord, taking into account the factors studied that will vary the length of time until the umbilical cord is separated.

SUBMITTER: Lopez-Medina MD

PROVIDER: S-EPMC6953818 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Umbilical cord separation time, predictors and healing complications in newborns with dry care.

López-Medina María Dolores MD López-Araque Ana Belén AB Linares-Abad Manuel M López-Medina Isabel María IM

PloS one 20200110 1

<h4>Objective</h4>The objective of this study was to explore the umbilical cord separation time, predictors, and healing complications from birth until the newborn was one month old.<h4>Design</h4>A quantitative longitudinal observational analytical study by stratified random sample was adopted.<h4>Setting</h4>Public health system hospitals in southern Spain and at newborns' homes.<h4>Participants</h4>Between April 2016 and December 2017, the study included 106 neonates born after 35-42 weeks of ...[more]

PMID: 31923218

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Project description:MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability as well as their dysregulation in disease has led to ongoing interest in their diagnostic and prognostic potential. Circulating microRNAs may be valuable predictors of early-life complications such as birth asphyxia or neonatal seizures but there are relatively few data on microRNA content in plasma from healthy babies. Here we performed small RNA-sequencing analysis of plasma processed from umbilical cord blood in a set of healthy newborns. MicroRNA levels in umbilical cord plasma of four male and four female healthy babies, from two different centres were profiled. A total of 1,004 individual microRNAs were identified, which ranged from 426 to 659 per sample, of which 269 microRNAs were common to all eight samples. Many of these microRNAs are highly expressed and consistent with previous studies using other high throughput platforms. While overall microRNA expression did not differ between male and female cord blood plasma, we did detect differentially edited microRNAs in female plasma compared to male. Of note, and consistent with other studies of this type, adenylation and uridylation were the two most prominent forms of editing. Six microRNAs, miR-128-3p, miR-29a-3p, miR-9-5p, miR-218-5p, 204-5p and miR-132-3p were consistently both uridylated and adenylated in female cord blood plasma. Although only a few microRNAs were differentially edited in females and expression levels were low, it is an interesting finding as the effects of sex on RNA editing is poorly understood and warrants further investigation. These results provide a benchmark for microRNA profiling and biomarker discovery using umbilical cord plasma and can be used as comparative data for future biomarker profiles from complicated births or those with early-life developmental disorders.

Dataset Information

Umbilical cord separation time, predictors and healing complications in newborns with dry care.

Publications

Umbilical cord separation time, predictors and healing complications in newborns with dry care.

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