A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.
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ABSTRACT:
SUBMITTER: Richardson TG
PROVIDER: S-EPMC6954187 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.
Richardson Tom G TG Hemani Gibran G Gaunt Tom R TR Relton Caroline L CL Davey Smith George G
Nature communications 20200110 1
Developing insight into tissue-specific transcriptional mechanisms can help improve our understanding of how genetic variants exert their effects on complex traits and disease. In this study, we apply the principles of Mendelian randomization to systematically evaluate transcriptome-wide associations between gene expression (across 48 different tissue types) and 395 complex traits. Our findings indicate that variants which influence gene expression levels in multiple tissues are more likely to i ...[more]
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