Ontology highlight
ABSTRACT:
SUBMITTER: D'Hulst G
PROVIDER: S-EPMC6954236 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
D'Hulst Gommaar G Soro-Arnaiz Inés I Masschelein Evi E Veys Koen K Fitzgerald Gillian G Smeuninx Benoit B Kim Sunghoon S Deldicque Louise L Blaauw Bert B Carmeliet Peter P Breen Leigh L Koivunen Peppi P Zhao Shi-Min SM De Bock Katrien K
Nature communications 20200110 1
mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1<sup>KO</sup>) reduces muscle mass. PHD1<sup>KO</sup> muscles show impaired mTORC1 activation in response to leucine whereas mTORC1 activation by growth factors or eccentric contractions was preserved. The ability of PHD1 to promote mTORC1 activity is independent of its hydroxylation a ...[more]