Ontology highlight
ABSTRACT:
SUBMITTER: Coghill AE
PROVIDER: S-EPMC6954331 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Coghill Anna E AE Proietti Carla C Liu Zhiwei Z Krause Lutz L Bethony Jeff J Prokunina-Olsson Ludmila L Obajemu Adeola A Nkrumah Francis F Biggar Robert J RJ Bhatia Kishor K Hildesheim Allan A Doolan Denise L DL Mbulaiteye Sam M SM
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20191016 1
<h4>Background</h4>The discovery of Epstein-Barr virus (EBV) in Burkitt lymphoma tumors represented the first link between a virus and cancer in humans, but the underlying role of this virus in endemic Burkitt lymphoma remains unclear. Nearly all children in Burkitt lymphoma-endemic areas are seropositive for EBV, but only a small percentage develop disease. Variation in EBV-directed immunity could be an explanatory cofactor.<h4>Methods</h4>We examined serum from 150 Burkitt lymphoma cases and 1 ...[more]