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Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.


ABSTRACT: OBJECTIVE:GCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity, type II diabetes and dyslipidemia in some populations, conditions that highly related to NAFL etiology. The present study aimed to evaluate the relationship between NAFLD and rs780094 polymorphism in patients with NAFLD in Tabriz city, northwest of Iran. The rs780094 polymorphism was determined in 74 patients with NAFLD by PCR-RFLP technique. Demographic information was collected using a questionnaire and biochemical analysis was performed using standard laboratory methods. RESULTS:There was a significant difference between case and control subjects for alanine aminotransferase, aspartate aminotransferase, HDL-C and triglycerides (P?

SUBMITTER: Mohammadi S 

PROVIDER: S-EPMC6954502 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.

Mohammadi Saba S   Farajnia Safar S   Shadmand Masoud M   Mohseni Fatemeh F   Baghban Roghayyeh R  

BMC research notes 20200110 1


<h4>Objective</h4>GCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity, type II diabetes and dyslipidemia in some populations, conditions that highly related to NAFL etiology. The present study aimed to evaluate the relationship between NAFLD and rs780094 polymorphism in patients with NAFLD in Tabriz city, northwest of Iran. The rs780094 polymorphism was determined in 74 patients with NAFLD by PCR-RFLP technique. Demographic information was collecte  ...[more]

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