Ontology highlight
ABSTRACT:
SUBMITTER: Azimi FC
PROVIDER: S-EPMC6954718 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Azimi Farshad C FC Lee Jeffrey E JE
Protein science : a publication of the Protein Society 20191129 2
Human immunodeficiency virus (HIV) is a retroviral pathogen that targets human immune cells such as CD4<sup>+</sup> T cells, macrophages, and dendritic cells. The human apolipoprotein B mRNA- editing catalytic polypeptide 3 (APOBEC3 or A3) cytidine deaminases are a key class of intrinsic restriction factors that inhibit replication of HIV. When HIV-1 enters the cell, the immune system responds by inducing the activation of the A3 family proteins, which convert cytosines to uracils in single-stra ...[more]