Ontology highlight
ABSTRACT:
SUBMITTER: Sui P
PROVIDER: S-EPMC6955216 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sui Pengfei P Li Rongbo R Zhang Yan Y Tan Chunting C Garg Ankur A Verheyden Jamie M JM Sun Xin X
Development (Cambridge, England) 20191216 24
The respiratory lineage initiates from the specification of NKX2-1<sup>+</sup> progenitor cells that ultimately give rise to a vast gas-exchange surface area. How the size of the progenitor pool is determined and whether this directly impacts final lung size remains poorly understood. Here, we show that epithelium-specific inactivation of <i>Mdm2</i>, which encodes an E3 ubiquitin ligase, led to lethality at birth with a striking reduction of lung size to a single vestigial lobe. Intriguingly, t ...[more]