Dataset Information

Rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report.

ABSTRACT: Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia.

SUBMITTER: Salami A

PROVIDER: S-EPMC6955813 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report.

Salami Ali A Costanian Christy C El Shamieh Said S

Journal of cardiovascular development and disease 20191030 4

Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). ...[more]

PMID: 31671579

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Rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report.

Publications

rs2569190A>G in <i>CD14</i> is Independently Associated with Hypercholesterolemia: A Brief Report.

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