Ontology highlight
ABSTRACT:
SUBMITTER: Mahanti M
PROVIDER: S-EPMC6956361 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Mahanti Mukul M Pal Kumar Bhaskar KB Sundin Anders P AP Leffler Hakon H Nilsson Ulf J UJ
ACS medicinal chemistry letters 20191204 1
A series of 3-deoxy-3-<i>N</i>-arylated-β-d-galactoside and -guloside derivatives have been synthesized by cesium fluoride/trimetylsilylaryl triflate-mediated benzyne generation and <i>N</i>-arylation of 3-deoxy-3-amino-β-d-galactosides and -gulosides, respectively. Evaluation as ligands to galectin-1, 2, 3, 4N (<i>N</i>-terminal domain), 4C (<i>C</i>-terminal domain), 7, 8N, 8C, 9C, and 9N revealed that the galactosides selectively bound galectin-9C, whereas the gulosides selectively bound gale ...[more]