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Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.


ABSTRACT:

Objectives

To assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model.

Materials and methods

In this prospective study, eleven pregnant rhesus macaques at day 98?±?5 of gestation were divided into three groups, untreated control (UC) (n?=?3), saline control (SC) (n?=?4) and interleukin 1 beta (IL-1?) treated (IT) (n?=?4), which were administered with either saline or IL-1? into the amniotic fluid. All animals were imaged at multiple time points before and after ferumoxytol administration (4?mg/kg). Longitudinal R2* and susceptibility of tissues were obtained using region-of-interest analysis and the longitudinal changes were assessed using linear mixed models and Student's t-test.

Results

In fetuses, a slope of 0.3?s-1/day (P?=?0.008), 0.00?ppm/day (P?=?0.699) and -?0.2?s-1/day (P?=?0.023) was observed in liver R2*, liver susceptibility, and lung R2*, respectively. In placentas, R2* and susceptibility increased immediately after ferumoxytol administration (P?ConclusionsThis work demonstrates the feasibility of quantitative ferumoxytol-enhanced MRI to measure dynamics of ferumoxytol delivery and washout in the placenta. Stable MRI measurements indicated no evidence of iron deposition in fetal tissues of nonhuman primates after maternal ferumoxytol exposure.

SUBMITTER: Zhu A 

PROVIDER: S-EPMC6956847 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.

Zhu Ante A   Reeder Scott B SB   Johnson Kevin M KM   Nguyen Sydney M SM   Fain Sean B SB   Bird Ian M IM   Golos Thaddeus G TG   Wieben Oliver O   Shah Dinesh M DM   Hernando Diego D  

Magnetic resonance imaging 20191023


<h4>Objectives</h4>To assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model.<h4>Materials and methods</h4>In this prospective study, eleven pregnant rhesus macaques at day 98 ± 5 of gestation were divided into three groups, untreated control (UC) (n = 3), saline control (SC) (n = 4) and interleukin 1 beta (IL-1β) treated (IT) (n = 4), which were administered with either saline or IL-1β into the amniotic fluid. All animals were imaged at multiple time point  ...[more]

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